The PLUS Trial 2018-01-31T16:52:54+13:00

The PLUS Trial

This large multicentre randomised trial will provide vital information for clinicians on the safety and efficacy of Plasma-Lyte 148® in comparison with saline that will inform and influence clinical practice in Australia and worldwide.

The PLUS Trial


  • Fluid resuscitation is a fundamental component of the management of critically ill patients and the choice of fluid is a longstanding issue of debate
  • Worldwide, 0.9% saline (”normal saline”) has traditionally been the most widely used resuscitation fluid, however its use is increasingly challenged by emerging evidence that its high chloride content may have clinically important adverse effects
  • Use of balanced crystalloid solutions such as Plasma-Lyte 148® may be associated with decreased mortality and decreased risk of acute kidney injury


Primary: To determine whether  fluid resuscitation and therapy with a “balanced” crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality in critically ill patients requiring  fluid resuscitation when compared with the same treatment using normal saline.


  • the study is prospective, multi-centre, parallel group, concealed, blinded, randomised, controlled trial
  • PLUS will compare two approaches to fluid resuscitation in critically ill adults in the ICU
  • the study will enrol 8,800 patients in ICUs in Australia and New Zealand


  • The National Health and Medical Research Council (NHMRC), Australia
  • Baxter Healthcare
  • The Health Research Council of New Zealand
  • The Medical Research Institute of New Zealand

Coordinating centre: The George Institute for Global Health, Sydney, Australia

Chief Investigator: Professor Simon Finfer, The George Institute for Global Health

Software: Spinnaker, Spiral Software


Read what people are saying about the PLUS Trial on Twitter


Read what people are saying about the PLUS Trial on Twitter.

Study Database

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Study Database

The PLUS Trial is enrolling. If you have a username and password you can sign in from here.
Study Database

View this trial on the U.S. National Library of Medicine website

View this trial on the U.S. National Library of Medicine website.