A multi-centre randomised controlled trial to determine if 7 days of intravenous β-lactam in combination with standard therapy will lead to better complication-free survival 90-days after randomisation, compared to standard therapy alone in patients with MRSA blood stream infection.
A phase 2b randomised controlled trial investigating the safety and efficacy of intravenous paracetamol versus placebo (5% dextrose) in the treatment of fever in critically ill patients with known or suspected infection.
A multi-centre, randomised, single blinded clinical trial comparing standard vs. conservative oxygen therapy in mechanically ventilated adults in the Intensive Care Unit.
A 52- week, open label, parallel group, multi-centre, phase III, randomised controlled trial to compare the efficacy and safety of three asthma treatment regimens. Recruitment in New Zealand, Australia, Italy and the United Kingdom.
A 52- week, open label, parallel group, multi-centre, phase III, randomised controlled trial to compare the efficacy and safety of two asthma treatment regimens. Recruitment in New Zealand only.
A novel, multi-centred cluster randomised double cross over feasibility trial
investigating the effect of using 0.9% saline or Plasma Lyte® 148 as fluid therapy in intensive care patients on the risk of developing acute kidney injury.
A stratified, prospective, multi-centre, unblinded, randomised, parallel-group phase II study to determine whether a supplemental parenteral nutrition strategy will reliably and safely increase energy intake when compared to usual care.
A 4,000 patient, multi-centre, double-blinded, randomised, controlled, parallel-group, phase III clinical trial to determine if augmentation of calorie delivery using energy dense enteral nutrition in mechanically ventilated patients improves 90 day survival when compared to routine care.