To determine the impact on 90-day mortality of:
- Alternative antibacterial strategies;
- Administration of azithromycin, acting as an immunomodulatory agent;
- Administration of a Corticosteroid;
A key benefit of the design is that additional questions can be asked over the lifetime of the platform.
To provide Australia and New Zealand’s contribution to the pre-prepared global research response to future pandemics of Severe Acute Respiratory Illness (SARI) by seamlessly and rapidly (within days) adapting the platform to test the most promising interventions for pandemic infection and providing trial results during the first wave of a pandemic.