The ICU-ROX Trial

The ICU-ROX Trial will test the hypothesis that, compared to a liberal approach, a conservative approach to oxygen delivery may reduce lung collapse (atelectasis), decrease the risk of new non- respiratory organ dysfunction, and might reduce 28-day mortality.

The ICU-ROX Trial

Background

  • More than 20,000 New Zealanders are admitted to an intensive care unit (ICU) annually. ICU patients are the sickest patients in the hospital and many require life support (mechanical ventilation).
  • Although supplemental oxygen is universally delivered to patients who require mechanical ventilation in the ICU, there is no level I evidence with respect to the most appropriate ‘dose’ of oxygen to provide to these patients.
  • It is generally accepted that abnormally low levels of oxygen should be avoided where possible; however, there is no consensus regarding the approach to abnormally high levels of oxygen in patients who require mechanical ventilation

Aims

Primary: To determine whether a conservative approach to oxygen therapy, which minimises unnecessary exposure to hyperoxaemia, will increase day 90 survival compared to a more liberal approach to oxygen therapy which does not specifically aim to avoid exposure to hyperoxaemia.

Methods

  • the study is a multicentre, parallel group randomised controlled superiority trial which will allocate ICU patients in a 1:1 ratio to liberal or conservative oxygen therapy
  • the study will compare two approaches to oxygen therapy in adults requiring mechanical ventilation in the ICU
  • the study will be conducted in ICUs in Australia and New Zealand

Supported by the Health Research Council of New Zealand

Coordinating centre: The Medical Research Institute of New Zealand

Chief Investigator: Dr Paul Young, Specialist in Intensive Care Medicine, Wellington Hospital

Twitter

Read what people are saying about the ICU-ROX Trial on Twitter

#ICUROXtrial

Read what people are saying about the ICU-ROX Trial on Twitter.
#ICUROXtrial

Study Database

Sign in to the study (username + password needed)

Study Database

The ICU-ROX Trial is open and enrolling patients. If you have a username and password you can sign in from here.
Study Database

ANZCTR

View this trial on the Australian and New Zealand Clinical Trial Registry

ANZCTR

View this trial on the Australian and New Zealand Clinical Trial Registry. 
ACTRN12615000957594